Acute ischemic stroke is a neurological emergency with high mortality and morbidity. Due to limited opportunities to participate in the emergency rescue of stroke， it is often difficult for neurology residents to master the diagnosis of acute ischemic stroke and intravenous thrombolysis therapy in the standardized training. Simulation-based training is an effective teaching method. Based on the clinical practice of cerebrovascular diseases in neurology， the teaching team designed a situational simulation for treatment of acute ischemic stroke according to the teaching objectives. The residents with standardized training conduct the role play in the designed situational simulation. This teaching method integrated treatment skills and simulation-based training for acute ischemic stroke. It is more closely related to clinical practice scenarios， can fully stimulate students' initiative， deepen their understanding of stroke theory knowledge and intuitive understanding of intravenous thrombolysis operations， improve their clinical thinking， communication skills， and team cooperation ability， thereby improving their professional treatment ability for acute ischemic stroke， and providing reference for cultivating qualified stroke emergency physicians.