Parkinson disease is a common neurodegenerative disease， characterized by movement disorders， and the etiology and pathogenesis of Parkinson disease are still not fully understood. Exosomes are small vesicles widely present in biological body fluids that carry various biological molecules， including RNA， and are involved in various physiological activities and pathological processes of cells. An increasing number of studies have shown that exosome non-coding RNAs play an important role in Parkinson disease. This paper reviews the research progress of exosome non-coding RNAs in the diagnosis and treatment of Parkinson disease. Although it is still in the research stage， with the deepening of scientific research， therapies based on exosome non-coding RNAs will bring new hope to Parkinson disease patients.