Objective To explore the current status and influencing factors of the quality of life of parents of children with epilepsy， so as to provide clinical basis for improving the quality of life of parents of children with epilepsy. Methods From January to December 2022， convenience sampling was used to select 310 parents of children with epilepsy in the Department of Neurology of Xi'an Children's Hospital as participants. A self-designed General Information Questionnaire and the Brief World Health Organization Quality of Life Instrument （WHOQOL-BREF） were used to investigate the current status of quality of life of parents of children with epilepsy. The generalized linear model was used to analyze the influencing factors of the quality of life of parents of children with epilepsy. Results The total score of WHOQOL-BREF for parents of children with epilepsy was （12.64±2.24）， and the scores for physiological， psychological， social， and environmental dimensions were （13.09±2.45）， （12.53±2.58）， （13.12±2.88）， and （11.81±2.55）， respectively， all of which were lower than the domestic norm， and the differences were statistically significant （t=-9.207， -14.517， -9.355， -5.015， -2.305； P＜ 0.05）. Generalized linear model analysis showed that the total WHOQOL-BREF score of parents of children with epilepsy was negatively correlated with the child's current residence in rural areas， comorbidities with epilepsy， lack of outdoor activities or frequency of outdoor activities 2 to 3 times per month， lack of vaccination after onset， and the difference was statistically significant （R2 =3.650，P＜ 0.05）.Conclusions Parents of children with epilepsy have poor quality of life. Parents of children with epilepsy comorbidities need to be given special attention. When appropriate， timely vaccination should be given to children with epilepsy to prevent infectious diseases， increase outdoor activity time， improve living environment， and enhance the level of medical and health care at the grassroots level， which is beneficial for improving the quality of life of parents of epilepsy children.