慢性疼痛患者的焦虑、抑郁现状分析
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辽宁省科学技术计划项目 (2019-BS-295)


Anxiety and depressive disorder status of chronic pain patients
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    摘要:

    目的 分析慢性疼痛患者的焦虑、抑郁情况。方法 选取 2023 年 1 月— 2024 年 1 月于中 国医科大学附属第一医院疼痛科住院的 455 例慢性疼痛患者为研究对象。采用视觉模拟量表(VAS)评 估患者的疼痛程度,采用广泛性焦虑量表(GAD-7)和患者健康问卷抑郁症状群量表(PHQ-9)评估患者 焦虑抑郁情况。比较不同疾病类型患者焦虑、抑郁情况。采用 Spearman 相关分析患者的年龄、VAS、 GAD-7、PHQ-9 评分的相关性。结果 本研究发放问卷 455 份,回收有效问卷 407 份,问卷有效回收率 为 89.45%。根据 ICD-11 慢性疼痛分类标准,将患者分为慢性术后及创伤后疼痛(Ⅰ组)38 例、慢性继发 性骨骼肌肉疼痛(Ⅱ组)127 例、慢性继发性内脏痛(Ⅲ组)18 例、慢性继发性头痛或颌面痛(Ⅳ组)39 例、慢 性神经病理性疼痛(Ⅴ组)71 例、慢性原发性疼痛(Ⅵ组)89 例和慢性癌性疼痛(Ⅶ组)25 例。7 组患者的性 别、PHQ-9 评分比较,差异无统计学意义(P> 0.05);年龄、VAS 评分、GAD-7 评分、疼痛持续时间比较, 差异有统计学意义(P< 0.05)。407 例患者中,焦虑患者占 60.37%(248/407),分别为轻度焦虑 164 例,中 度焦虑 53 例,重度焦虑 31 例;抑郁患者占 67.57%(275/407),分别为轻度抑郁 132 例,中度抑郁 89 例,中 重度抑郁 46 例,重度抑郁 8 例。7 组患者的 GAD-7 总分比较,差异有统计学意义(χ2 =13.596,P=0.034); PHQ-9 总分比较,差异无统计学意义(χ2 =5.417,P=0.492)。相关分析结果显示,慢性疼痛患者 VAS 评分 与患者年龄、GAD-7、PHQ-9 评分呈正相关(r=0.105、0.210、0.216,P< 0.05);GAD-7 评分与 PHQ-9 评分 呈正相关(r=0.647,P< 0.05)。结论 慢性疼痛患者焦虑抑郁发生率较高,患者焦虑严重程度与抑郁严 重程度呈正相关。

    Abstract:

    Objective To explore the anxiety and depressive disorder status of patients with chronic pain. Methods From January 2023 to January 2024, 455 chronic pain patients admitted to the Pain Department of the First Affiliated Hospital of China Medical University were selected as participants. Visual Analogue Scale (VAS), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) were used to assess patients' pain, anxiety, and depressive disorder, respectively. Spearman correlation was used to analyze the correlation between patients' age, VAS, GAD-7, and PHQ-9 scores. Results A total of 455 questionnaires were distributed, and 407 valid questionnaires were collected, with a valid response rate of 89.45%. According to the International Classification of Diseases 11th Revision (ICD-11) chronic pain classification criteria, patients were divided into 38 cases of chronic postsurgical or post traumatic pain (Group Ⅰ), 127 cases of chronic secondary musculoskeletal pain (Group Ⅱ), 18 cases of chronic secondary visceral pain (Group Ⅲ), 39 cases of chronic secondary headache or orofacial pain (Group Ⅳ), 71 cases of chronic neuropathic pain (Group Ⅴ), 89 cases of chronic primary pain (Group Ⅵ), and 25 cases of chronic cancer related pain (Group Ⅶ). There was no statistically significant difference in gender and PHQ-9 score among 7 groups of patients (P > 0.05), but there was a statistically significant difference in age, VAS score, GAD- 7 score, and duration of pain (P < 0.05). Among the 407 patients, anxiety patients accounted for 60.37% (248/407), and depressive disorder patients accounted for 67.57% (275/407). Among the 407 patients, there were 164 cases of mild anxiety, 53 cases of moderate anxiety, and 31 cases of severe anxiety, and there were 132 cases of mild depressive disorder, 89 cases of moderate depressive disorder, 46 cases of moderate to severe depressive disorder, and 8 cases of severe depressive disorder. Among the 7 groups of patients, there was a statistically significant difference in the total score of GAD-7 (χ2 =13.596, P=0.034), but there was no statistically significant difference in the total score of PHQ-9 (χ2 =5.417, P=0.492). Correlation analysis showed that VAS scores of chronic pain patients were positively correlated with age, GAD-7, and PHQ-9 scores (r=0.105, 0.210, 0.216; P< 0.05), and GAD-7 scores were positively correlated with PHQ-9 scores (r=0.647, P < 0.05), and the differences were statistically significant. Conclusions Chronic pain patients have a high incidence of anxiety and depressive disorder, and the severity of anxiety is positively correlated with the severity of depressive disorder.

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宋雨晴,宋涛,董道松,万成福.慢性疼痛患者的焦虑、抑郁现状分析[J].神经疾病与精神卫生,2024,24(9):665-670
DOI :10.3969/j. issn.1009-6574.2024.09.010.

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  • 在线发布日期: 2024-10-08