急性期老年期抑郁障碍住院患者自杀风险的相关因素分析
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北京市教育委员会科技发展计划一般项目 (KM202010025011)


Related factors of suicide risk in hospitalized late life depression at acute phase
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    摘要:

    目的 比较急性期不同自杀风险老年期抑郁障碍(LLD)住院患者的临床特征,并探究其 自杀风险相关因素。方法 回顾性分析 2021 年 7 月— 2022 年 12 月在首都医科大学附属北京安定医院 就诊的伴有自杀风险的 118 例急性期 LLD 住院患者为研究对象,其中伴有自杀观念 65 例(自杀观念组)、 伴有自杀未遂行为 53 例(自杀未遂组)。比较两组患者的一般资料、汉密尔顿焦虑量表(HAMA)得分、 24 项汉密尔顿抑郁量表(HAMD-24)得分。比较患者的血清促肾上腺皮质激素(ACTH)、皮质醇、血清总 甲状腺素(TT4)、血清三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状 腺素(TSH)及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、 雌二醇及睾酮等水平。采用二项 Logistic 回归分析 LLD 住院患者自杀未遂的相关因素。结果 自杀 未遂组的 FT3 水平低于自杀观念组,TSH 水平、HAMD-24 总分、认知障碍因子得分、绝望感因子得分、 HAMA 中精神性焦虑因子得分均高于自杀观念组,差异均有统计学意义(均P< 0.05)。二项 Logistic 回 归分析结果显示,FT3(OR=0.410,P=0.019)、精神性焦虑因子得分(OR=1.192,P=0.029)是 LLD 住院患者 自杀未遂的相关风险因素。结论 与 LLD 自杀观念患者相比,住院 LLD 有自杀未遂患者甲状腺功能水 平偏低、抑郁症状较重;FT3 水平、精神性焦虑因子得分是 LLD 住院患者自杀未遂的相关因素。

    Abstract:

    Objective To compare the clinical characteristics of hospitalized patients with late life depression (LLD) at different suicide risks in the acute phase, and explore the related factors of suicide risks. Methods A retrospective analysis was conducted on 118 patients with LLD at risk of suicide, admitted to Beijing Anding Hospital, Capital Medical University during acute phase from July 2021 to December 2022, including 65 with suicidal ideation(suicidal ideation group) and 53 with attempted suicide behaviour(attempted suicide group). The general clinical data, and the scores of Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale-24 (HAMD-24) were compared. The following pathology results among patients in different groups were compared, including adrenocorticotropic hormone(ACTH), cortisol, serum total thyroxine(TT4), triiodothyronine(T3), free triiodothyronine(FT3), free thyroxine(FT4), thyroid-stimulating hormone(TSH), total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), estradiol, testosterone, etc. The related factors of attempted suicide in hospitalized LLD patients were analyzed by binomial logistic regression. Results Compared with the suicide ideation group, the FT3 level was lower in the attempted suicide group. Compared with the suicide ideation Objective To compare the clinical characteristics of hospitalized patients with late life depression (LLD) at different suicide risks in the acute phase, and explore the related factors of suicide risks. Methods A retrospective analysis was conducted on 118 patients with LLD at risk of suicide, admitted to Beijing Anding Hospital, Capital Medical University during acute phase from July 2021 to December 2022, including 65 with suicidal ideation(suicidal ideation group) and 53 with attempted suicide behaviour(attempted suicide group). The general clinical data, and the scores of Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale-24 (HAMD-24) were compared. The following pathology results among patients in different groups were compared, including adrenocorticotropic hormone(ACTH), cortisol, serum total thyroxine(TT4), triiodothyronine(T3), free triiodothyronine(FT3), free thyroxine(FT4), thyroid-stimulating hormone(TSH), total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), estradiol, testosterone, etc. The related factors of attempted suicide in hospitalized LLD patients were analyzed by binomial logistic regression. Results Compared with the suicide ideation group, the FT3 level was lower in the attempted suicide group. Compared with the suicide ideation

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甄文凤,杨婧,汪晓,马向林,张庆娥.急性期老年期抑郁障碍住院患者自杀风险的相关因素分析[J].神经疾病与精神卫生,2024,24(12):837-843
DOI :10.3969/j. issn.1009-6574.2024.12.001.

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  • 在线发布日期: 2024-12-30