Glioma is the most common primary intracranial malignant tumor. Due to the strong genetic variation and significant individual differences among patients， as well as the difficulty in generating new mutations and antigens during the progression of glioblastoma， the research progress of targeted therapy has encountered more obstacles compared to other tumors. Immunotherapy and tumor-treating fields （TTF） are new concepts in cancer treatment， and their phased breakthroughs have greatly inspired the field of glioma research. This article provides an overview of the new discoveries and advances in the treatment of gliomas in recent years， to provide reference for future clinical treatment of gliomas.