早发性精神分裂症静息态脑功能连接研究新进展
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2022 年安徽省转化医学研究院科研基金(2022zhyx-B01);安徽省高等学校科学研究项目(2022AH050671);2019 年度国家临床重点专科能力建设项目(皖财社[2019]1166 号);2022 年度新时代育人质量工程项目(2022gjxslt010)


New progress in the research of resting state brain functional connectivity in early-onset schizophreni
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    摘要:

    近年来的观点认为,精神分裂症是一种脑功能连接障碍,而功能连接是指大脑不同区域之 间低频波动的统计时间相关性。早发性精神分裂症作为一种严重的精神疾病,同样存在着脑功能连接的 改变,但其与脑功能连接的关系仍不明确,因此一直是近些年研究的热点。静息态脑功能情况反映了大 脑在静息状态下的活动模式。随着脑功能连接分析方法的不断进步,静息态脑网络功能连接为了解和识 别精神分裂症、建立精神分裂症的诊断模型、提高患者的预后提供了重要的技术支撑。本文对静息态 脑网络功能连接、早发性精神分裂症患者脑功能连接的改变以及脑功能连接与早发性精神分裂症患者 核心症状的相关性进行综述,为了解早发性精神分裂症的生理机制及寻找治疗靶点提供思路和参考。

    Abstract:

    In recent years, it has been considered that schizophrenia is a disorder of brain functional connectivity. The functional connectivity refers to the statistical temporal correlation of low-frequency fluctuations between different regions of the brain. As a serious mental disease, early-onset schizophrenia also has changes in brain function connection. However, the relationship between early-onset schizophrenia and brain function connection is still not clear, making it a hot research topic in recent years. The resting state of brain function reflects the pattern of brain activity in a resting state. With the continuous advancement of brain functional connectivity analysis methods, the functional connectivity of resting brain network provides important technical support for understanding and identifying schizophrenia, establishing diagnostic models of schizophrenia, and improving the prognosis of patients. This article aims to review the changes in resting-state brain network functional connectivity and brain functional connectivity in early-onset schizophrenia, as well as the correlation between brain functional connectivity and core symptoms in early-onset schizophrenia, in order to provide ideas and references for understanding the physiological mechanism of early-onset schizophrenia and exploring therapeutic targets.

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申晴晴,夏磊,郝明茹,刘寰忠.早发性精神分裂症静息态脑功能连接研究新进展[J].神经疾病与精神卫生,2025,25(2):77-82
DOI :10.3969/j. issn.1009-6574.2025.02.001.

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  • 在线发布日期: 2025-02-27