CD147 belongs to the immunoglobulin superfamily and is a transmembrane glycoprotein that participates in normal metabolism and pathological processes of diseases by binding to multiple factors. Recent studies show that the expression of CD147 is significantly increased in glioma cells， which plays a crucial role in the proliferation， invasion， and metastasis of gliomas. In addition， CD147 enhances the glycolytic activity of glioma cells through the Warburg effect， which not only accelerates tumor growth but is also closely related to the formation of tumor treatment resistance. Therefore， CD147 holds promise as a potential target for glioma treatment. Based on this， this paper reviews the structure， function， and mechanism of CD147 in tumors， as well as its expression and impact in gliomas， in order to provide clinical reference.