Objective To investigate the effects of person-centered care on mental symptoms， selfesteem and general well-being in schizophrenia patients. Methods A total of 68 patients with schizophrenia in a community of Shanghai who met the inclusion criteria were selected and randomly divided into intervention group and control group， with 34 cases in each. The community-based general rehabilitation was used in the control group. The intervention group adopted the comprehensive rehabilitation service mode which is guided by the concept of person-centered care. The severity of mental symptoms was assessed by Positive and Negative Syndrome Scale（ PANSS）， self-esteem by Self-esteem Inventory（ SEI）， overall well-being by General Well- Being Schedule（ GWBS）. Results After 12 months of intervention， the differences in PANSS score， SES score and GWBS score between the two groups were statistically significant（ t=-11.246， 3.194， 4.618； P＜0.01）. In the intervention group， there were statistical significances in the differences in PANSS score and GWBS score between before and after intervention（ F=45.011， 6.006； P ＜ 0.01）. However， there was no significant difference in SEI scores before and after intervention（ F=1.535，P ＞ 0.05）. Conclusions Rehabilitation services based on the concept of complex in community schizophrenics can help alleviate the mental symptoms of schizophrenia patients， improve their low self-esteem， and enhance overall well-being.