Objective To explore the risk factors of ischemic stroke recurrence and the recurrence of different TOAST subtypes， and to provide the basis for the prevention of ischemic stroke recurrence. Methods The first episode ischemic stroke cases were collected continually from the Neurology Department of the Second Hospital of Hebei Medical University between October 1st， 2014 and February 1st， 2015. Selfdesigned questionnaires were used in research， including general demographic data， medical history， test results and other information. The patients were communicated by phone for 1 year， from the onset， to the recurrence of stroke， lost to follow-up， or death. Follow-up contents includes recurrence， drug taking and other medical situations. Results This study collected 501 cases in total， including 28 cases with incomplete data and 23 lost to follow up cases. Eventually， 450 available cases were used in research including 306 male and 144 female， aged from 16 to 81. The average age is 59.5 years old. There were 76 cases in recurrence group， and 374 cases in non recurrence group. In TOAST types， 327（ 72.7%） cases were large artery atherosclerosis， 92（ 20.4%） cases were small artery occlusion， 18（ 4.0%） cases were cardioembolism， 5（ 1.1%） cases were stroke of other determined cause， 7（ 1.5%） were stroke of undetermined cause. The recurrence rates of 3 m onthes， 6 monthes， 1 year were 4.9%， 8.4% and 16.9% respectively. Results of the Logistic regression with single factor and multi factors showed that hyperhomocysteinemia（ OR=2.376， 95%CI=1.349-4.183）， transient ischemic attack（ OR=2.791，95% CI=1.538-5.066）， bad compliance of antiplatelet drugs（ OR=1.941，95%CI=1.116- 3.374）， cardioembolism（ OR=1.941，95%CI=1.116-3.374） were the risk factors of ischemic stroke recurrence. Conclusions Ischemic stroke has a certain recurrence rate. Hyperhomocysteinemia， transient ischemic attack，bad compliance of antiplatelet drugs are the independent risk factors of ischemic stroke recurrence.TOAST types can be used as predictor for recurrence of ischemic stroke， and cardioembolism is the independent risk factors of ischemic stroke recurrence.