Objective To identify efficacy and value of early rehabilitation in the treatment of severe stroke. Methods A total of 134 cases of severe stroke patients were recruited for early rehabilitation， including cognitive function training， motor function training and daily life activity training. The Mini-Mental State Examination （MMSE）， the FugI-Meyer Assessment（ FMA） and the Barthel Index（ BI） were applied 24 hours before treatment and 4 weeks after treatment. Results Comparing the results before and after the patients' early rehabilitation， MMSE［ （19.16±8.86） vs（ 22.33±7.36）］， FAM［ （34.08±22.21） vs（ 53.96±24.79）］， BI［ （35.38±19.83） vs （61.78±18.88）］. The scores were significantly increased after treatment， and the differences were statistically significant（ P ＜ 0.05）. Conclusions Early rehabilitation plays a significant role in reducing post-stroke cognition and motor dysfunction， and can reduce the disability rate and improve patients' quality of life.