Objective To compare the difference between low-energy electroconvulsive therapy（ LECT） and modified electroconvulsive therapy（ MECT） in the efficacy and adverse reactions of schizophrenia in female patients. Methods The female patients with schizophrenia enrolled were randomly divided into LECT group and MECT group， with 20 cases in each group. The LECT group energy setting was 2.8 joules. The energy Joule of the conventional MECT group was set to be slightly larger than 1/2 of the patients' age. Adverse effects were assessed by the rate of decline in the Positive and Negative Symptoms Scale（ PANSS）， and the adverse reactions were recorded. Results The scores of the LECT group and the MECT group were（ 3.3±1.5） and（ 4.4±2.0） respectively on the negative symptom scale（ PANSS-N）， and the difference was statistically significant（ t=2.059， P=0.046）. The scores of LECT group and the MECT group on the positive symptom scale（ PANSS-P） and the general psychopathological symptom scale（ PANSS-G） were［ （7.1±2.7） vs（ 9.0±3.8）］ and［ （10.5±3.8） vs （13.0±5.2）］ respectively， there was no statistical significance. The number of adverse reactions in the LECT group and the MECT group was 6 and 58 respectively， and the difference between groups was statistically significant（ χ2=15.000，P＜ 0.001）. Conclusions LECT was not inferior to conventional MECT in efficacy， but significantly decreased in adverse reactions.