The tachykinin/ tachykinin receptors are widely distributed in the central nervous system of the brain， especially in the limbic system associated with emotion. Accumulating evidence has indicated that the tachykinin/ tachykinin receptors may contribute to the pathophysiology of depression. This article reviews the research on the relationship between tachykinin/ tachykinin receptors and depression， and it may enrich the understanding of the pathological processes of depression and provide insights into therapeutic approaches for its treatment.