Objective To analyze the clinical characteristics and risk factors of patients with pulmonary thromboembolism（ PTE） after operation； and explore the application value of PTE risk prediction score（ Wells score， Geneva score） combined with Pulmonary Embolism Rule-Out Criteria（ PERC） score in postoperative patients with neurologic tumors. Methods The clinical data of 56 patients with PTE after operation of neurologic tumors were retrospectively analyzed in Sanbo Brain Hospital of Capital Medical University from June 2016 to June 2019. Their clinical characteristics， risk factors， and laboratory examinations were analyzed， retrospectively. The general information of patients， such as medical record number， gender， age， height， body weight， smoking history， drinking history， previous venous thromboembolism history， previous basic disease history and tumor pathological diagnosis， as well as clinical features and auxiliary examinations， including clinical symptoms， signs， perioperative clinical information， imaging examination（ CTPA）， venous thrombosis risk factors， as well as treatment and prognosis， The Karnofsky（ KPS） scores at admission， discharge and diagnosis of PTE were evaluated. The Wells score and Geneva score were calculated as high， medium and low， and PERC score was evaluated. The value of Wells score， Geneva score and PERC score in the diagnosis of PTE after operation of neurologic tumors was analyzed. Results There were 35 males and 21 females among the 56 patients， with an average age of（ 46.23±18.12） years. The common symptoms were dyspnea and disturbance of consciousness， accounting for 73.21%（ 41/56） and 35.71%（ 20/56）， respectively. The common signs of shortness of breath， tachycardia and deep venous thrombosis（ DVT） accounted for 66.07%（ 37/56）， 46.43%（ 26/56） and 53.57%（ 30/56）， respectively. PTE occurred 9.00（ 4.75，14.00） days after operation. The average preoperative fasting time was（ 9.50±2.82） hours. The average time span from the beginning of anesthesia to extubation consciously is（ 683.2±295.5） min. Pathological results showed malignant tumor in 20 cases， accounting for 35.71%， and 36 benign tumors， accounting for 64.29%. According to the tumor location， there were 26 cases （46.43%） of sellar tumors， 21 cases（ 37.50%） of supratentorial tumors， 7 cases of skull base tumors（ 12.50%）， and 2 cases of spinal cord tumors（ 3.57%）. Among them， 55 patients underwent anticoagulation therapy alone， and 1 patient underwent vena cava filter placement + anticoagulation therapy； 4 patients（ 7.14%） died in the hospital. All patients had an average Wells score of（ 7.19±1.70） and a Geneva score of（ 7.44±1.85）， all of which belonged to the middle and high risk groups. The average PERC score was（ 4.18±1.20）， recognized as positive cases. Conclusions The underlying cause of acute PTE after neurological tumor surgery is complicated， and the clinical manifestations are not specific. PTE risk prediction score（ Wells score， Geneva score） combined with PERC score and auxiliary laboratory tests are helpful for early diagnosis of pulmonary embolism.