Objective Based on the voxel-based degree centrality（ DC） analysis， to investigate the characteristics of resting state brain network node centrality and the neuroimaging mechanism of cognitive impairment in patients with first-episode depression. Methods From May 2013 to March 2019， totally 30 patients with first-episode depression in Renming Hospital of Wuhan University（ MD group） and 30 healthy controls（ NC group） were included in the study. All subjects underwent resting-state fMRI. Then Digital Symbol Test（ DST）， Digital Span Test（ DSPT）， and Verbal Fluency Test（ VFT） were performed. The resting state fMRI data were routinely preprocessed， and the DC map of each group was calculated. The DC value and cognitive function test score of the two groups were compared by double sample t-test. Pearson correlation was used to analyze the correlation between the DC value and cognitive function test scores. Results （1）Compared with NC gorup， MD group showed decreased score in DST［ （62.37±10.30） vs（ 70.47±10.12）］， DSPT ［forward：（ 8.20±0.76） vs（ 9.27±1.12）； backward（ 5.30±1.15） vs（ 5.73±1.56）］， and VFT［ （19.50±2.57） vs （22.57±4.45）］， and the differences were statistically significant（ P＜0.01）.（ 2） Compared with NC group， the DC value of the left superior frontal gyrus decreased， while the DC value of the right occipital calarine cortex， right middle cingulate cortex， right striatum increased in patients with first-episode depression（ P＜0.01， AlphaSim correction， voxel number ＞ 55）.（ 3） The Pearson correlation analysis showed that the DC value of the right striatum was negatively correlated with DST score of patients with first-episode depression（ r=-0.48，P=0.01），while the DC value of the left superior frontal gyrus was positively correlated with the DSPT score and VFT score （r=0.38， P=0.04； r=0.41， P=0.03）. Conclusions There are changes in centrality of brain network nodes in patients with first episode of depression. These brain regions are mainly located in the right occipital cortex， the middle of right cingulate gyrus， the right striatum and the left superior frontal gyrus. The changes of the central position of the network nodes in the right striatum and the left superior frontal gyrus are closely related to the cognitive impairment of patients， which will provide a possible neuroimaging basis for exploring the neuroimaging mechanism of cognitive impairment in depression.