With the increasing aging of the population， the number of patients with Alzheimer disease （AD） is growing year by year. Early screening， early detection and early intervention have become the strategy and consensus for the prevention and treatment of AD， so the research on noninvasive peripheral biomarkers is particularly important. This article mainly reviews and summarizes the research progress of domestic scholars on urine biomarkers of AD in the past decade. Most of the research findings in the references come from the detection and observation of human urine samples. It suggests that we should pay attention to the exploration and application of noninvasive peripheral biomarkers， which provide a new perspective as well as new ideas for the early diagnosis and early intervention of diseases.