Deficit schizophrenia is a subtype of primary schizophrenia， whose main clinical features are primary， persistent negative symptoms. Compared with non-deficit schizophrenia， patients with deficit schizophrenia have earlier onset age， more severe cognitive disorders， more obvious long-term mental recession， and a heavier disease burden. Through the retrieval and analysis of the existing literature both in China and abroad， this paper reviews the pathogenesis， diagnosis， and therapy of deficit schizophrenia， in order to improve the early recognition of the disease and strengthen intervention.