Depressive disorder is a common psychosocial disease with a high incidence in worldwide， and its etiology and pathogenesis are complex. Recent studies have found that the nuclear transcription factor c-Myc may play a certain role in the occurrence and progression of depressive disorder. Starting from the pathological mechanism of depressive disorder and combining with modern molecular biology， this paper systematically summarizes and explores the association between c-Myc and depressive disorder， aiming to elucidate the role of c-Myc in progression of depressive disorder and provide new ideas for the clinical treatment of depressive disorder.