Depressive disorder is a common mental illness with a high prevalence and disability rate， and patients are often accompanied by self-injurious suicidal behavior and varying degrees of impaired social functioning， which creates a serious burden on society. Commonly used monoamines are slow-acting and prone to relapse， so exploring new antidepressant targets and approaches is a process necessary to address the current state of depressive disorder treatment. The hippocampus is an important brain region for human emotion regulation. This review analyzes and summarizes the role of the hippocampus and its neural circuits in the pathogenesis and treatment of depressive disorder， aiming to provide new ideas and possible targets for the treatment of depressive disorder.