Bipolar disorder （BD） is a chronic recurrent mental disorder that seriously affects the quality of life of patients and is one of the top 10 causes of the global burden of disease. Internet gaming disorder （IGD） is currently a recognized problem that affects the lives and physical and mental health of people who use online games worldwide， and is one of the mental disorders that deserves further research. Currently， the application of structural and functional imaging techniques has been widely studied on brain structure and brain biochemical metabolism in patients with BD and IGD， and brain structural changes such as thinning of the parietal lobe， the anterior cingulate gyrus， the frontal cortex， and reduction in surface area， as well as brain biochemical metabolism changes such as decreased levels of N-acetyl aspartate in the frontal lobe in the patients of the two groups have been found to be both differences， and these changes correlate with clinical features. This paper reviews the characteristic changes in brain structure and brain biochemical metabolites of BD and IGD patients， and explores the similarities and differences between the brain structure and brain biochemical metabolisms of BD and IGD patients， with the aim of providing reference for neuroimaging markers， neurobiological mechanisms， and diagnostic methods and early intervention of the co-morbidity of BD with IGD.