Depressive disorder， as a highly heterogeneous mental disorder， has a complex pathogenesis. Studies suggest that FAM19A5 may be involved in the pathogenic process of depressive disorder. To visualize the research progress and influence of FAM19A5， this paper uses VOSviewer software to conduct visual analysis on all English literature retrieved using the keyword "FAM19A5" in PubMed. Based on publication volume， authors， keywords， and other visual graphs， research trends and directions are analyzed. The relationship between FAM19A5 and depressive disorder is comprehensively analyzed through relevant literature， and various forms are used to explore and elucidate the role of FAM19A5 in the pathogenesis of depressive disorder， aiming to provide new ideas for the clinical treatment of depressive disorder.