White blood cells， especially neutrophils， are crucial for defending against infections caused by important pathogens such as bacteria and fungi. When it is significantly reduced， life-threatening complications may occur. In clinical practice， leukopenia/neutropenia caused by non-chemotherapy drugs is often asymptomatic in its early stages， making it difficult to detect promptly and potentially leading to serious complications. Nearly all major categories of psychiatric drugs are associated with leukopenia/neutropenia， which may occur at any time during treatment， and the risk is difficult to predict. Therefore， enhancing awareness of psychiatric drug-induced leukopenia/neutropenia is particularly important for psychiatrists. This article provides a review of the incidence， clinical characteristics， mechanisms， and conventional treatment methods for leukopenia/neutropenia induced by commonly psychiatric drugs.