Temporal interference stimulation（ TIS）， an emerging non-invasive deep neural modulation technique， generates a low-frequency envelope field through two high-frequency currents that interfere within the body. This allows for precise modulation of deep brain regions while maintaining a low intensity of electrical stimulation at the surface. Studies have shown that TIS is well-tolerated and safe， and modulatory effects on specific neural circuits have been observed in both animal experiments and early human trials. However， numerous key scientific questions regarding the mechanism of action of TIS， optimization of multi-parametric stimulation modes， targeting characteristics of different brain regions， principles of cross-species transformation， and its clinical effects in neuropsychiatric disorders remain to be systematically elucidated. Based on the latest research advances， this structured review examines the electrophysiological and neurobiological mechanisms of TIS， evidence from animal models， and the feasibility and efficacy of preliminary clinical studies. This paper also focuses on the potential applications and challenges of TIS in neuropsychiatric disorders such as Parkinson's disease and depressive disorders.