Objective To study the effects of group cognitive behavioral therapy on stigma and medication compliance in patients with bipolar disorder. Methods Totals of 25 patients with bipolar disorder were divided into study group (16 cases) and control group (9 cases) by paired design. The study group received group cognitive behavioral therapy on the basis of routine treatment. While the control group received routine treatment. Internalized Stigma of Mental Illness scale (ISMI) and Medication Adherence Rating Scale (MARS) were measured in two groups. Results In stigma， after 10 sessions， stereotype endorsement improved significantly in the study group (P ＜0.05). Alienation， stereotype endorsement， perceived discrimination and total scores of ISMI improved statistically after treatment within the study group (P ＜ 0.05). While within the control group， scores of ISMI and subscales showed no significant differences before and after treatment (P ＞ 0.05). In the medication compliance， there were no significant differences between two groups before and after treatment (P＞0.05). The scores of MARS improved statistically within the study group after treatment (P＜0.05). While within the control group， scores of MARS showed no significant difference before and after treatment (P＞ 0.05). Conclusions Group cognitive behavioral therapy can reduce stigma， improve medication compliance and promote rehabilitation for patients with bipolar disorder.