Objective To explore the related risk factors of subjective cognitive impairment (SCI) to provide references for prevention. Methods Fifty-four patients admitted to Shanghai Changzheng Hospital from March to September of 2016 were evaluated by Mini-mental State Examination (MMSE) and self-made questionnaire. Univariate and multivariate logistic regression analyses were performed on related exposure factors. Results By univariate and multivariate logistic regression analyses， three meaningful independent factors were screened out. Age (OR=1.243， 95%CI=1.072-1.442) and history of cerebrovascular diseases (OR=130.466， 95%CI=1.688-3 630.660) were independent risk factors of SCI， while education level (OR=0.016， 95%CI=0.007- 0.607) was an independent protective factor. Conclusions Age and history of cerebrovascular diseases are risk factors of SCI. It’s necessary to enhance the prevention of the risk factors. Education level is an independent protective factor. So the aged people should be advocated and encouraged to use their brains and think more.