Objective To explore the correlation between dysfunctional attitudes and aggressivity， and the mediation effect of depression between dysfunctional attitudes and aggressivity in order to explore ways to protect mental health in college students. Methods Totals of 1 050 college students in Shandong province were included to fill the questionnaire. The correlation between dysfunctional attitudes and aggressivity， and the mediation effect of depression between dysfunctional attitudes and aggressivity were analyzed. Results Physical aggression， verbal aggression， hostility， self-aggression， mandatory， seeking approval， cognitive of philosophy and depression were significantly different between male and female college students (P＜ 0.05). Factors in anger showed significant differences between only child and not-only child (P＜0.05). Dysfunctional attitudes were related with aggressive factors (P＜ 0.05)， except for cognitive of philosophy， verbal aggression and anger. Depression showed partial mediation effect between dysfunctional attitudes and aggressivity， accounting for 16.32% of the total effect. Conclusions Dysfunctional attitudes are associated with aggressivity. Depression shows partial mediation effect between dysfunctional attitudes and aggressivity.