Objective To investigate the status of medicine compliance in secondary prevention of ischemic stroke， in order to provide evidence for the secondary prevention. Methods Data of 242 continuous ischemic stroke patients in Urumqi were prospectively collected. Information of medicine and reasons of ceasing durgs was registered in 12 months. Results The rate of taking antithrombotic drugs one year after discharged was 55.8%（135/242）. The nationality（ OR=4.007， 95%CI=1.768-9.080）， degree of education（ OR= 2.953， 95%CI=1.493-5.840）， pattern of payment（ OR=0.189， 95%CI=0.060-0.594）， dyslipidemia（ OR=0.424， 95%CI=0.217-0.831） were associated with treatment compliance one year after discharged. The rate of taking stains one year after discharged was 59.9%（145/242）. The degree of education（ OR=3.613， 95%CI=1.844- 7.082）， pattern of payment（ OR=0.254， 95%CI=0.091-0.711）， dyslipidemia（ OR=0.340， 95%CI=0.179-0.648） were associated with compliance of medicine one year after discharged. The rates of taking hypotensor and hypoglycemic agent one year after discharged were 71.9%（138/192） and 64.8%（59/91）. The main reasons of poor compliance of antithrombotic drugs and stains were symptoms improved and ignoring the treatment. The main reasons of poor compliance of hypotensor and hypoglycemic agent were indicators improved and ignoring the treatment. Conclusions The treatment compliance in secondary prevention of ischemic stroke patients is generally poor. The clinicians should focus on the secondary prevention guidance.