Emptiness is an inner-subjective experience. It is primarily an internal defect or an empty feeling， associated with weakness and helplessness， which may usually leads to negative behavior like avoidance， addiction and even self-mutilation and suicide. The study reviews the predictive value of emptiness for mental diseases， focusing on the predictive function of emptiness on three categories of mental diseases： compulsive buying， borderline personality disorder， and the emptiness of suicide. Future research should further clarify the connotation and denotation of emptiness， clarifying the predictive value of emptiness for mental illness， and expanding the depth and breadth of emptiness research.