Post stroke depression（ PSD） refers to a group of affective disorder syndrome after stroke. The diagnosis of PSD depends on the diagnostic criteria of the symptomatology of depression， and disease assessment requires mastering the time and scope of the relevant assessment scale. At present， researches on the risk factors of PSD involve neural function， metabolism， psychosocial and oxidative stress. Prevention of PSD mainly includes drug intervention and psychological intervention. Besides that， physical therapy and traditional Chinese medicine also gradually show the advantages in preventing disease. Identifying high-risk groups and improving interventions for PSD can significantly reduce the incidence， recurrence rate and mortality of PSD， and improve the prognosis of patients with stroke.