CRMP2 is highly expressed in the developing and adult nervous systems and regulates skeletal dynamics by interacting with cytoskeletal proteins. It plays an important role in the development of nervous system and neuroplasticity， and is closely related to the occurrence of many neuropsychiatric diseases. There are many post-translational modifications（ PTMs）， including phosphorylation， oxidation， proteolysis and ubiquitination. Among them， the most important modification is phosphorylation. Phosphorylation of CRMP2 can affect its binding to the cytoskeletal proteins and other downstream molecules， then affect many functions of the nervous system. This article reviews the posttranslational modifications and related signaling pathways.