Objective To evaluate the clinical efficacy of argatroban combined with aspirin and clopidogrel on the treatment of antiplatelet therapy in acute cerebral infarction， and explore the active and effective treatment of acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction were recruited and randomly divided into two groups. One is argatroban with aspirin and clopidogrel group（ the treatment group， 40 cases） and the other is aspirin and clopidogrel group（ the control group， 40 cases）. To evaluate the therapeutic effect，NIHSS scores were performed 7 and 14 days before and after treatment in both two groups， ADL scores were performed before and 14 days after treatment. Results The NIHSS score of the treatment group was significantly lower than that of the control group 14 days after treatment（ P＜ 0.05）；The ADL score of treatment group was significantly higher than that of the control group 14 days after treatmen（t P＜0.01）； There was no obvious adverse reaction in both groups. Conclusions It is safe and effective to treat acute progressive cerebral infarction with argatroban combined with aspirin and clopidogrel. It is more effective than aspirin and clopidogrel treatment and to be worthy of clinical promotion.