Objective To explore the characteristics of stigma in Tibetan patients with firstepisode depression and compare with those of Chinese Han patients， and to analyze the relationship between personalities and stigma in Tibetan depressed patients. Methods A total of 60 Tibetan patients and 60 Chinese Han patients with first-episode depression were selected as subjects. The Link Stigma Scale and the Big Five Personality Scale were respectively used to investigate stigma of disease and personalities. Results In the Link stigma scale， the score of regression factor of Tibetan patients was higher than that of Chinese Han patients， which was（ 2.45±0.25） and（ 2.33±0.24） respectively（ t=-2.082，P＜0.05）. In the Big Five Personality Scale， the neuroticism of Tibetan patients was lower than that of Chinese Han patients， which was（ 3.16±0.51） and （3.79±0.64） respectively（ t=2.153，P＜ 0.05）. The score of extroverted factors of Tibetan patients was higher than that of Chinese Han patients， which was（ 2.78±0.63） and（ 2.22±0.68） respectively（ t=2.747，P＜0.05）. Among Tibetan patients， the score of openness factor of Big Five Personality Scale is negatively correlated with the score of Discrimination-perception Scale and Emotional Experience Scale（ r=-0.337，-0.311； P＜0.01）. While conscientiousness factor score was positively correlated with both（ r=0.404， 0.375；P＜0.01）. Neuroticism score was positively correlated with the score of Discrimination-perception Scale（ r=0.305，P＜0.01）. Conclusions Tibetan patients with first-episode depression have different stigma with Chinese Han people and are affected by personalities.