Schizophrenia is a kind of chronic serious mental disease with impaired cognitive， emotional， behavioral and social functions. Animal models of schizophrenia have been widely used in the study of etiology， mechanism of drug action and new drug development. Good animal model construction will help to solve the difficult problems in disease research. This article reviews the relationship between the types of animal models of schizophrenia and the pathogenesis of schizophrenia， and provides literature basis for the study of animal experimental studies of schizophrenia