Objective To investigate the abnormality of the node centrality of the white matter network in patients with schizophrenia and its relationship with clinical symptoms. Methods A total of 49 patients with schizophrenia were enrolled in the study. A total of 36 healthy people with matched gender， age and education were selected as the control group. The Positive and Negative Symptom Scales were used to evaluate the clinical symptoms of the patients； the GRETNA software was used to calculate the node centrality values of all subjects； the partial correlation analysis method was used to explore the relationship between the centrality values and clinical symptoms in patients with schizophrenia. Results Compared with the control group， the node centrality of the cerebral white matter networks was abnormal. The degree of centrality in the experimental group was significantly lower in the right insula， precuneus， superior temporal gyrus， left anterior cingulate gyrus， central anterior gyrus， orbital frontal gyrus， parahippocampal gyrus and superior parietal gyrus［ P＜ 0.005， false discovery rate（ FDR） correction］； the degree of centrality of the left anterior cingulate gyrus was negatively correlated with the negative symptom factors（ r=-0.622，P＜ 0.001）. Conclusions The cerebral white matter network of schizophrenia patients has abnormal degree of centrality in multiple brain regions compared with the health control， and such abnormality may be related to the pathophysiological mechanism of schizophrenia.