Alcohol dependence causes profound damage to brain. Alcohol dependence is associated with brain shrinkage， memory and attention deficits， communication disorders and physical disabilities. Monocyte chemoattractant protein-1（ MCP-1） is one of the key chemokines that regulate the recruitment and activation of monocytes and microglia. Both MCP-1 and its receptor C-C chemokine receptor type 2（ CCR2） are involved in various neuro inflammatory disorders. Recent evidence indicates that alcohol exposure increased the activity of MCP-1/CCR2 in central nervous systems. MCP-1/CCR2 inhibition can alleviate alcohol neurotoxicity by reducing neuro inflammation in the brain and spinal cord. In this review， we discussed the role of MCP-1/ CCR2 signaling in alcohol-induced neuro inflammation and brain damage.