Eating disorder （ED） is a common mental disorder with abnormal eating behavior as the main clinical manifestation. The pathology is still unclear and the treatment is difficult. The prevalence rate of anorexia nervosa （AN） increases gradually and the mortality rate is as high as 5%～20%. At present， the research on the neurobiological mechanism of AN has been increasing. The results show structural and functional changes in the brain of AN. This study discusses the key findings， in order to provide some theoretical basis for future research.