Objective To evaluate the cognitive function and anxiety， depression and mental symptoms of people at high risk of schizophrenia， and provide scientific basis for early intervention of this population. Methods A total of 109 healthy children of schizophrenia outpatients and inpatients from the First Affiliated Hospital of China Medical University and Shenyang Mental Health Center were selected as the genetic high-risk group （HR） of schizophrenia. A healthy control group （HC） of 109 healthy children matched with age， gender， and years of education were recruited by advertising. The two groups completed the Wisconsin Card Sorting Test （WCST）， MATRICS Consensus Cognitive Battery （MCCB）， Hamilton Anxiety Scale （HAMA）， Hamilton Depression Scale （HAMD-17）， and Brief Psychiatric Rating Scale （BPRS）. The general demographic data， cognitive status， and clinical characteristics of the two groups of subjects were analyzed. Results （1）The total number of correct （Z=-4.54，P＜ 0.01）， correct classification （Z=-3.78，P＜ 0.01）， total number of errors （Z=-4.49，P ＜ 0.01）， the number of persistent errors （Z=-3.91，P ＜ 0.01） and the number of non-persistent errors （Z=-3.38，P＜ 0.01） were significantly different for the HR group from the HC group， （2）The HR group's total score of MCCB （t=11.58，P＜ 0.01）， symbol coding （t=11.25，P＜ 0.01）， visual spatial memory （t=4.59， P=0.04）， and continuous operation test （t=6.18，P=0.02） were significantly lower than those of the HC group；the total HAMA score （t=2.54，P＜ 0.01）. （3）The total HAMD-17 score （t=3.03，P＜ 0.01）， the somatic anxiety factors （t=2.70，P ＜ 0.01） and core depression factors （t=3.04，P ＜ 0.01） in the depression scale in the HR group were significantly higher than those in the HC group. （4） The total score of BPRS （t=3.14，P ＜ 0.01）， anxiety and depression factor scores （t=2.90，P＜ 0.01） in the HR group were significantly higher than the HC group. Conclusions Cognitive functions are impaired in individuals at high risk of schizophrenia and anxiety， depression， and mental symptoms are higher than the healthy population.