Abstract:Objective To compare the visual nystagmus (VNG) manifestations of vestibular migraine (VM) and healthy subjects, and to clarify the diagnostic value of VNG in VM. Methods A prospective analysis of 55 patients with VM and 45 healthy patients who were treated in the Department of Neurology in the Affiliated People's Hospital of Xinxiang Medical University from August 2018 to August 2019 was conducted. All subjects were were examined with VNG under the permitted conditions, including optokinetic test (saccade test, stationary tracking experime, optokinetic nystagmus examination), vestibular function test (caloric test, head shaking nystagmus), spontaneous nystagmus test, evoked nystagmus test (static position nystagmus). χ2 test was used to compare the differences in VNG results between the two groups. Results There was no significant demographic difference between VM group and healthy subjects group (P > 0.05). Saccade test: There were 17 abnormalities in the VM group (30.9%) and 3 (6.7%) in the healthy subjects group (χ2 =9.091,P < 0.05). Stationary tracking experiment: There were 20 patients (36.4%) were abnormal in the VM group, and 5 (11.1%) in the healthy group (χ2 =8.418,P< 0.05). Optokinetic nystagmus examination: There were 24 cases (43.6%) were abnormal in the VM group, and 6 (13.3%) in the healthy group (χ2 =10.823,P < 0.05). Caloric test: There were 13 cases (23.6%) were abnormal in the VM group, 2 (3.6%) in the healthy subject group (χ2 =7.150, P< 0.05). Head shaking nystagmus: There were 11 cases (20.0%) were abnormal in the VM group , 2 (3.6%) in the healthy subject group(χ2 =5.295, P< 0.05); Spontaneous nystagmus: There were 10 patients (18.2%) were abnormal in the VM group, and 4 (8.9%) in the healthy subject group (χ2 =1.775,P > 0.05). Static position nystagmus: There were 22 abnormalities (40.0%) in the VM group and 7 (16.5%) in the healthy subject group (χ2 =7.183, P< 0.05). Conclusions The abnormal rate of total VNG examination in the VM group was higher than that in the healthy subject group, indicating that the VNG examination is helpful for the diagnosis of VM, and its performance suggests signs of damage to the center and periphery of VM patients.