Schizophrenia is a common， unexplained， and serious mental disease which often involves a lifetime with high prevalence rate， high recurrence rate and high disability rate. Patients with recurrent schizophrenia have severe repercussions， including cognitive dysfunction， impaired social function， and quality of life decline. Recent researches on related factors of schizophrenia relapse are relatively scattered. This article reviews the definition and related factors of schizophrenia relapse.