As one of the most common forms of stroke， acute ischemic stroke is currently treated by reperfusion， including intravenous thrombolytic therapy and intravascular therapy. Intravenous thrombolysis within 6 hours after the onset of acute ischemic stroke can improve the prognosis. However， intravenous thrombolysis also has the risk of hemorrhagic transformation， which may adversely affect the early improvement of neurological function and long-term prognosis of patients. Current studies suggest that inflammatory reaction is mainly involved in the physiological and pathological mechanism of hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke. In this paper， the risk predictors of the correlation between inflammatory response and hemorrhagic transformation after intravenous thrombolysis are reviewed in order to provide evidence for the early identification and prevention of hemorrhagic transformation after intravenous thrombolysis.