As a chronic mental disease， depression has the characteristics of high morbidity， high recurrence rate， and high suicide and disability rate. Drug therapy， as the main treatment method at present， has been attracting the attention of clinical medical workers for its onset rate（its rapid onset and slow response）. Rational use of antidepressants can enhance patients' medication compliance and reduce their suicide risk. This paper summarizes the research progress on the overview of the onset time of various antidepressants， the relevant factors affecting the onset time of antidepressants， and the mechanism by which individual antidepressant synergist accelerates the onset time of antidepressants， so as to provide reference for medical staff and literature basis for accurate decision-making of drug use.