Objective To explore the characteristics of the suicide and the related factors in children and adolescents with depressive disorder. Methods From January 2018 to December 2019， a total of 389 children and adolescents admitted to Hebei Provincial Sixth People's Hospital with depressive disorder were recruited， with 171 patients in suicide group， and 218 patients in non-suicide group. The general and clinical information were compared between the two groups. Logistic regression was used to analyze the related factors of the suicide in children and adolescents with depressive disorder. Results There were significant differences between the two groups in age（ t=-2.23， P=0.026）， physical diseases（ χ2=5.65， P=0.017）， psychotic symptoms （χ2=4.28， P=0.038）， sleep disorder（ χ2=5.69， P=0.017） and the treatments（ drug treatments： χ2=40.31， P＜ 0.001； pyschological treatments： χ2=5.81， P=0.016）. Logistic regression analysis showed that age（OR=0.59， 95%CI： 0.45-0.78）， psychotic symptoms（OR=2.20，95%CI： 1.02-4.76） and physical diseases（ OR=0.08， 95%CI： 0.04-0.18） were related to suicide. Conclusions Age， psychotic symptoms and physical diseases are the related factors to the suicide in children and adolescents with depressive disorder.