An increasing number of studies have confirmed ketamine can exert a robust and rapid onset of antidepressant effect. Most of the current clinical evidences were from studies in adult patients， while the efficacy and safety of ketamine have not been sufficiently evaluated in adolescent treatment-resistant depression （TRD）. The aim of this study was to review the research progress of ketamine in the acute treatment of adolescent TRD， aiming to provide a basis for ketamine's clinical application in adolescent patients.