Parkinson disease is a common degenerative disease of the central nervous system. Pain is a common non-motor symptom of Parkinson disease， with a prevalence of 40%-85%. Pain symptoms seriously affect the quality of life of patients with Parkinson disease， and its mechanism is complex. In the neurodegenerative process of Parkinson disease， the degree of neuronal loss in locus coeruleus is greater and earlier than that in substantia nigra compacta. Locus coeruleus contains the largest group of noradrenergic neurons in the central nervous system. Noradrenergic neurons provide a wide range of nerves throughout the brain to dominate and participate in the internal control of pain. This paper mainly introduces the research progress on the pathological mechanism of pain mediated by noradrenergic system injury in locus coeruleus in Parkinson disease