Alzheimer disease （AD） is one of the most common chronic diseases in the elderly. The prevalence of AD is closely related to age. Synaptic structure， as a key part of information transmission between neurons， is closely related to AD. The loss of synaptic structure and function is considered to be a sign of early AD. Postsynaptic density protein-95， shank and Homer proteins are the main postsynaptic scaffold proteins， which play an important role in maintaining synaptic structure and function. We systematically describe the research progress of postsynaptic scaffold proteins and AD.