Parkinson disease （PD） is a common neurodegenerative disease， of which pathogenesis remains unclear. An increasing number of studies have indicated mitochondrial dysfunction may play a key role in the development of PD. Numerous mitochondrial-associated risk genes for PD have been identified. This article reviews the progress of mitochondrial-associated genes and the treatment of mitochondrial dysfunction in PD， aiming to deepen the understanding of the role of mitochondria in PD.