Panic disorder is a common mental disorder often accompanied by dysfunction of the autonomic nervous system. Heart rate variability is an important indicator for evaluating autonomic nervous system function， and a reduction in this indicator is considered a manifestation of autonomic nervous system dysfunction. This paper summarizes the differences in heart rate variability between patients with panic disorder and healthy individuals， other anxiety disorder patients， and cardiovascular disease patients， and reviews the effects of medication and psychotherapy on heart rate variability in patients with panic disorder， aiming to provide reference for effective treatment of panic disorder.