Objective To explore the impact of negative life events and psychological resilience on suicide behavior in adolescents with depressive disorder. Methods From April 2021 to June 2023， convenience sampling was used to select 217 adolescents with depressive disorder at the Mental Health Center of the First Hospital of Hebei Medical University as participants. According to the MINI International Neuropsychiatric Interview （MINI）， individuals with a history of attempted suicide were divided into two groups of attempted suicide group （n=49） and non-attempted suicide group （n=168）. Hamilton Depression Scale （HAMD）， Childhood Trauma Questionnaire-Short Form （CTQ-SF）， Adolescent Self-rating Life Events Check List （ASLEC）， and Connor-Davidson Resilience Scale （CD-RISC） were used to assess the patient's depressive disorder， childhood trauma， life events， and psychological resilience， respectively. Univariate analysis and binomial Logistic regression were used to analyze the influencing factors of suicide behavior in adolescents with depressive disorder. Results Among 217 adolescents with depressive disorder， the incidence of suicide behavior was 22.58% （49/217）. Univariate analysis showed that there were statistically significant differences in the age of onset， school bullying， non-suicidal self-injury， suicidal ideation， HAMD score， CTQ total score， emotional abuse score， interpersonal relationship score， psychological resilience total score， hardiness score， and optimism score between the two groups of patients （all P ＜ 0.05）. Binomial Logistic regression analysis showed that school bullying ［OR=2.473， 95%CI （1.036， 5.902）］， suicidal ideation ［OR=10.206， 95%CI （1.909， 54.557）］， high emotional abuse scores ［OR=1.213， 95%CI （1.076， 1.368）］， and high interpersonal relationship scores ［OR=1.139， 95%CI （1.041， 1.246）］were risk factors for suicide behavior in adolescents with depressive disorder （P ＜ 0.05）， while high optimism scores ［OR=0.845， 95%CI （0.719， 0.993）］were protective factors for suicide behavior， and the differences were statistically significant （P＜ 0.05）. Conclusions The incidence of suicide behavior is higher in adolescents with depressive disorder. School bullying， suicidal ideation， emotional abuse， and poor interpersonal relationships are risk factors for suicide behavior， while good psychological resilience is a protective factor for suicide behavior.