Objective To evaluate the effects of digital technology interventions on the relapse or recurrent in patients with major depressive disorder. Methods Two researchers independently searched PubMed， Cochrane Library， Embase， PsycINFO， China National Knowledge Infrastructure （CNKI）， Wanfang and China Biology Medicine （CBM） databases for randomized controlled trials on the effect of digital technology interventions on the relapse or recurrent in patients with major depressive disorder from inception to May 26th， 2024. Revised-JADAD scale was used to evaluate the quality of included studies. The GRADE guideline was performed to rate the quality of evidence. The meta-analysis of the effects of digital techrology interventions on relapse or recurent in patients with major depressive disorder was conducted with the "metan" package of Stata MP 18.0 software. Results Seven randomized controlled trials and 1 436 patients were finally included in the data synthesis. The results showed that compared with the control group， digital technology interventions could effectively reduce the proportions of relapses or recurrent in patients with major depressive disorder （RR=0.63， 95%CI=0.47-0.83， I 2 =68.4%， P=0.004）. Subgroup analysis found that different types of digital technologies， study duration and study sites could be the source of heterogeneity. Of them， internet-delivered cognitive behavior therapy and rehabilitation training program had better effects in reducing the proportions of relapses and recurrent in patients with major depressive disorder. Conclusions Digital technology interventions had benefits in improving the relapse and recurrent in patients with major depressive disorder.