Objective To explore the family influencing factors of self-injury suicide behavior in adolescents with mood disorders. Methods From December 2020 to December 2021， 137 adolescents with mood disorders in Beijing Anding Hospital， Capital Medical University were selected for the study. The General Information Questionnaire， Adolescent Non-Suicidal Self-Injury Assessment Questionnaire （ANSAQ）， Barratt Impulsiveness Scale （BIS）， Family Assessment Device （FAD）， and Short-Egna Minnenav Barndoms Uppfostran （s-EMBU） were used to assess the patients' non-suicidal self-injury behaviors， impulsive personality traits， problems with family functioning， and quality of parenting style. Patients were categorized into no-suicidal self-injury group （n=46） and self-injury suicide group （n=91） based on whether or not they had self-injury suicide behavior in the past year. Factors influencing self-injury suicide behavior were analyzed using binomial Logistic regression. Results There were more patients ≤ 16 years of age in self-injury suicide group than in no-suicidal self-injury group， and the difference was statistically significant （χ2 =3.967， P=0.046）. Compared with no-suicidal self-injury group， patients in self-injury suicide group had higher BIS motor impulsivity scores ［（29.44±7.23） vs. （24.96±7.06）］， s-EMBU rejection subscale maternal and paternal scores ［（11.52±5.08） vs. （9.53±3.36）， and （11.08±4.51） vs. （9.50±3.81）］ with statistically significant differences （t=3.436， 2.380， 1.989； P ＜ 0.05）. Compared to no-suicidal self-injury group， self-injury suicide group had lower BIS cognitive impulsivity and unplanned impulsivity scores ［（29.84±7.84） vs. （34.02±8.08）， （27.64±8.94） vs. （31.93±8.54）］， FAD total functioning factor scores ［（28.59±3.14） vs. （29.96±3.15）］， and s-EMBU emotional warmth subscale paternal and maternal scores ［（17.03±5.80） vs. （19.18±5.07）， and （18.33±5.52） vs. （20.33±4.73）］， and the differences were statistically significant （t=-2.902，-2.682，-2.385， -2.082，-2.083； P＜0.05）. Binomial Logistic regression showed that positive family history ［OR=3.061， 95%CI （1.086， 8.632）］， high BIS motor impulsivity factor score ［OR=1.090，95%CI （1.028，1.156）］， total FAD functional factors ［OR=0.861， 95%CI （0.749，0.990）］， and low s-EMBU emotional warmth-paternal score ［OR=0.914， 95%CI （0.84， 0.987）］ were influencing factors for self-injury suicide behavior in adolescents with mood disorders， and the differences were statistically significant （all P＜ 0.05）. Conclusions Adolescents with positive family history， impulsive personalities， fathers with poor emotional acceptance and support for their children， and poor family function may be prone to self-injury suicide behavior.